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Experimental and computational methods for enabling structure-based drug discovery

14th March 2019
Wellcome Genome Campus Conference Centre, Hinxton, Cambridgeshire, CB10 1RQ

08.30 Registration and coffee
09.55 Welcome and introduction
Session 1
Chair: TBC
10.00 Julien Orts, ETH Zurich
‘Protein-ligand complex binding pocket structure determination with NMR2, the NMR molecular replacement method'
10.40 David Gloriam, University of Copenhagen
‘New computational methods and online resources for GPCR drug discovery'
11.20 Bonnie Wallace, Birkbeck College
‘The structure of the NavMs voltage-gated sodium channel as a target for antiepileptic, analgesic and antiarrhythmic state-specific drug design'
12.00 Lunch
Session 2
Chair: TBC
13.30 Katharina Duerr, Nuffield Department of Medicine, Structural Genomics Consortium
‘Crystals or grids? Integrating cryo-EM into the SGC membrane protein pipeline'
14.10 Alex Breeze, Astbury Biostructure Laboratory
‘Disease states of FGFR kinases probed using NMR and biophysics'
14.50 Coffee break
Session 3
Chair: TBC
15.10 Michael Hennig, leadXPro
‘X-ray Free Electron Laser: Opportunities for drug discovery'
15.50 Chris Tate, MRC-LMB Cambridge
‘Shedding light on G protein bias: structures of GPCRs coupled to G proteins determined by cryo-EM and X-ray crystallography'
16.30 Closing comments and end of meeting


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